Nassar, F. (2025). GENETIC DIVERSITY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX BY USING LEI0258 MICROSATELLITE MARKER ASSOCIATED WITH PRODUCTIVE PERFORMANCE AND VIRAL DISEASES IN BROILER BREEDERS. Egyptian Poultry Science Journal, (), -. doi: 10.21608/epsj.2025.69994.1153
Farid Nassar. "GENETIC DIVERSITY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX BY USING LEI0258 MICROSATELLITE MARKER ASSOCIATED WITH PRODUCTIVE PERFORMANCE AND VIRAL DISEASES IN BROILER BREEDERS". Egyptian Poultry Science Journal, , , 2025, -. doi: 10.21608/epsj.2025.69994.1153
Nassar, F. (2025). 'GENETIC DIVERSITY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX BY USING LEI0258 MICROSATELLITE MARKER ASSOCIATED WITH PRODUCTIVE PERFORMANCE AND VIRAL DISEASES IN BROILER BREEDERS', Egyptian Poultry Science Journal, (), pp. -. doi: 10.21608/epsj.2025.69994.1153
Nassar, F. GENETIC DIVERSITY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX BY USING LEI0258 MICROSATELLITE MARKER ASSOCIATED WITH PRODUCTIVE PERFORMANCE AND VIRAL DISEASES IN BROILER BREEDERS. Egyptian Poultry Science Journal, 2025; (): -. doi: 10.21608/epsj.2025.69994.1153
GENETIC DIVERSITY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX BY USING LEI0258 MICROSATELLITE MARKER ASSOCIATED WITH PRODUCTIVE PERFORMANCE AND VIRAL DISEASES IN BROILER BREEDERS
Articles in Press, Accepted Manuscript, Available Online from 19 May 2025
Department of Animal Production, Faculty of Agriculture, Cairo University, Giza 12613, Egypt. Department of Animal and Fish Production, College of Agricultural and Food Sciences, King Faisal University, P.O. Box. 400, Al-Ahsa 31982, Saudi Arabia
Abstract
The chicken Major Histocompatibility Complex (MHC) is strongly associated with resistance and susceptibility to many diseases. Moreover, selection for genetic resistance to diseases is a critical goal in the poultry breeding industry, which needs to be accurately balanced with other traits, including live body weight (LBW) and meat yield. The microsatellite marker LEI0258 is used to evaluate the effect of selection for 12 generations for high LBW at 6 weeks of age (LBW6) with natural selection against Marek disease (MD) on genetic component associated with resistance to MD and Newcastle diseases (ND) in Cairo B-2 line, local broiler breeders, compared with commercial broiler breeder line (AA line). Results indicated that, Cairo B-2 line had lower carcass parts with higher internal organs percentages compared to AA line. In addition, there was a positive association between 473 bp allele of LEI0258 with regard to LBW6 and carcass traits in two lines. Moreover, LEI0258 alleles 357 bp and 295 bp were present with high content in Cairo B-2 line only, which increased the genetic resistance to Marek’s disease and increased the humural immune response against ND vaccination in Cairo B-2 line than AA line. The association between these critical economic traits and LEI0258 microsatellite will facilitate the selection process by applying marker-assisted selection in Cairo B-2 line breeding program in the future.
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